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Suggestion of technology for manufacturing parts of a hydraulic press
Gryc, David ; Mouralová, Kateřina (referee) ; Zemčík, Oskar (advisor)
An introduction of hydraulic press and description of his main parts. An analysis of the given components and a proposal for the most suitable intermediate was made. A selection of tools and gauges for individual operations has been done. A proposition of manufacturing process and enumeration of machines times was proposed. Economic evaluation containing costs for intermediate, tools, workmen’s wages and energy for operating machines has been calculated.
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Solution technology of manufacturing for part "disc of coupler"
Borek, Vít ; Osička, Karel (referee) ; Mouralová, Kateřina (advisor)
An introduction to main principles of coupling and description of basic types has been done. An analysis of the given component and a proposal for suitable intermediate was made. A selection of machines and tools for individual operations has been done. A proposition of technologic process and enumeration of machines times was proposed. Economic evaluation containing costs for tools, cooperation, workmen’s wages, intermediate and energy for operating machines has been calculated.
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Analysis and isolation of intermediates involved in the biosynthetic pathway of alkylproline derivatives
Cudlman, Lukáš ; Bosáková, Zuzana (advisor) ; Michalíková, Klára (referee)
(EN) This work aims at preparation, analysis and isolation of intermediates of biosynthetic pathways of 4-alkyl-L-proline derivatives for their structural elucidation. Compounds with incorporated 4-alkyl-L-proline derivatives include clinically used lincosamide antibiotic, lincomycin A, antitumor pyrrolobenzodiazepines and bacterial hormone hormaomycin. Detailed knowledge of biosynthetic pathways of these biological active substances can be used to prepare new, more efficient derivatives. The first part of this work focuses on yellow-coloured dicarboxylic intermediates 1 and 2 of the biosynthetic pathway of 4-propyl-L-proline - the precursor of lincomycin A. In the presence of the methylation agent, S-adenosyl-L-methionine, and LmbW C- -methyltransferase, 1 was partially converted into intermediate 2. Using ultra-high performance liquid chromatography, both intermediates were identified from absorption and mass spectrometry spectra. A semi-preparative chromatographic method for isolation of both intermediates was developed. Surprisingly, a significantly lower stability of 2 compared to intermediate 1 was observed in an in vitro enzymatic reaction mixture. The second part of the work focuses on 4-ethylidene-L-proline - the precursor of tomaymycin belonging to pyrrolobenzodiazepines. After...
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Comparative Analysis of Chemistry Education ( Czech Republic - Scotland)
Laburdová, Jiřina ; Klímová, Helena (advisor) ; Teplý, Pavel (referee)
Key words: Scotland, Czech Republic, education system, Chemistry education, Chemistry teaching, National Qualifications, Standard Grade, Intermediate, Higher, Advanced Higher Abstract: The education system in the Czech Republic is currently undergoing many changes. Education systems of foreign countries are often what inspire us to make these changes. The aim of this thesis is to describe the education system in Scotland and the way chemistry is being taught at secondary schools in this country. Further it tries to compare these to the education system and chemistry teaching in the Czech Republic and consider whether we can adopt any aspects of Scottish education. Apart from analysis of study plans and educational documents, research for this thesis included visits to chemistry lessons at three secondary schools in Scotland and interviews with teachers at these schools. In the text, cultural and historical context of Scotland related to the education system is mentioned briefly. Then the Scottish education system is explained and Chemistry teaching at secondary schools is described from the point of study plans and requirements. The following chapter contains a description of schools that have been visited, together with reports from selected chemistry lessons. Last chapter then compares various aspects of...
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Analysis and isolation of intermediates involved in the biosynthetic pathway of alkylproline derivatives
Cudlman, Lukáš ; Bosáková, Zuzana (advisor) ; Michalíková, Klára (referee)
(EN) This work aims at preparation, analysis and isolation of intermediates of biosynthetic pathways of 4-alkyl-L-proline derivatives for their structural elucidation. Compounds with incorporated 4-alkyl-L-proline derivatives include clinically used lincosamide antibiotic, lincomycin A, antitumor pyrrolobenzodiazepines and bacterial hormone hormaomycin. Detailed knowledge of biosynthetic pathways of these biological active substances can be used to prepare new, more efficient derivatives. The first part of this work focuses on yellow-coloured dicarboxylic intermediates 1 and 2 of the biosynthetic pathway of 4-propyl-L-proline - the precursor of lincomycin A. In the presence of the methylation agent, S-adenosyl-L-methionine, and LmbW C- -methyltransferase, 1 was partially converted into intermediate 2. Using ultra-high performance liquid chromatography, both intermediates were identified from absorption and mass spectrometry spectra. A semi-preparative chromatographic method for isolation of both intermediates was developed. Surprisingly, a significantly lower stability of 2 compared to intermediate 1 was observed in an in vitro enzymatic reaction mixture. The second part of the work focuses on 4-ethylidene-L-proline - the precursor of tomaymycin belonging to pyrrolobenzodiazepines. After...
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Comparative Analysis of Chemistry Education ( Czech Republic - Scotland)
Laburdová, Jiřina ; Klímová, Helena (advisor) ; Teplý, Pavel (referee)
Key words: Scotland, Czech Republic, education system, Chemistry education, Chemistry teaching, National Qualifications, Standard Grade, Intermediate, Higher, Advanced Higher Abstract: The education system in the Czech Republic is currently undergoing many changes. Education systems of foreign countries are often what inspire us to make these changes. The aim of this thesis is to describe the education system in Scotland and the way chemistry is being taught at secondary schools in this country. Further it tries to compare these to the education system and chemistry teaching in the Czech Republic and consider whether we can adopt any aspects of Scottish education. Apart from analysis of study plans and educational documents, research for this thesis included visits to chemistry lessons at three secondary schools in Scotland and interviews with teachers at these schools. In the text, cultural and historical context of Scotland related to the education system is mentioned briefly. Then the Scottish education system is explained and Chemistry teaching at secondary schools is described from the point of study plans and requirements. The following chapter contains a description of schools that have been visited, together with reports from selected chemistry lessons. Last chapter then compares various aspects of...
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Suggestion of technology for manufacturing parts of a hydraulic press
Gryc, David ; Mouralová, Kateřina (referee) ; Zemčík, Oskar (advisor)
An introduction of hydraulic press and description of his main parts. An analysis of the given components and a proposal for the most suitable intermediate was made. A selection of tools and gauges for individual operations has been done. A proposition of manufacturing process and enumeration of machines times was proposed. Economic evaluation containing costs for intermediate, tools, workmen’s wages and energy for operating machines has been calculated.
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Solution technology of manufacturing for part "disc of coupler"
Borek, Vít ; Osička, Karel (referee) ; Mouralová, Kateřina (advisor)
An introduction to main principles of coupling and description of basic types has been done. An analysis of the given component and a proposal for suitable intermediate was made. A selection of machines and tools for individual operations has been done. A proposition of technologic process and enumeration of machines times was proposed. Economic evaluation containing costs for tools, cooperation, workmen’s wages, intermediate and energy for operating machines has been calculated.
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